Pseudo-color images of a mouse kidney section using LOSOM to reveal DAPI fluorescent staining for nuclear material, relief-like structures and multi-modality images.

Courtesy: Peng Xi

Peng Xi, associate professor of the Department of Biomedical Engineering, and his team’s research paper, “Laser oblique scanning optical microscopy (LOSOM) for phase relief imaging” (Optics Express, 20(13), 14100-14108, 2012)” was chosen among June’s “Top 10 Downloads in Optics Express.”

For the first time, Xi group introduced a novel optical phase relief imaging technique named Laser oblique scanning optical microscopy (LOSOM). Based on confocal laser scanning microscope, and through applying a fluorescent medium and oblique illumination/detection, LOSOM can achieve phase relief imaging for transparent biological specimens. Compared to conventional optical microscopes, it simplifies the experimental setup for getting rid of polarized components. Meanwhile, LOSOM is compatible with conventional fluorescence labeled specimen for multi-modality imaging.

Dr. Peng Xi is dedicated to the research of biomedical optics, and his research interest includes: STED super-resolution microscopy, confocal laser scanning microscopy, multi-photon microscopy, and optical coherence tomography (OCT).

Some of the recent publications and media reports of Xi group are listed below:

1. Laser oblique scanning optical microscopy (LOSOM) for phase relief imaging

2. Sciencenet.cn Researchers realized STED super-resolution nanoscopy

3. Achieving λ/10 Resolution CW STED Nanoscopy with a Ti:Sapphire Oscillator

4. CRAFT: Multimodality confocal skin imaging for early cancer diagnosis

5. OCTNews.org has reported their OCT work on Feature of the Week.